Christian McCaffrey headlines winners and losers of 49ers' MNF winTyler Dragon, USA TODAYTue, November 25, 2025 at 4:36 AM UTC·4 min readChristian McCaffrey got revenge against the Carolina Panthers, leading the San Francisco 49ers to a 20-9 win against his former team.
The NFC battle was a sloppy game on both sides, but McCaffrey was a steady force all night.
AdvertisementAdvertisementAdvertisementSan Francisco’s defense was stout. They allowed just nine points and 12 first downs.
Monday’s victory keeps the 49ers (8-4) within striking distance of the NFC West-leading Los Angeles Rams (9-2) and Seattle Seahawks (8-3), who are second in the division.
The Panthers (6-6) are a half game behind the Tampa Bay Buccaneers (6-5) in the NFC South.
NFL PLAYOFF PICTURE: 49ers solidify spot, alter NFC South order
Here are the winners and losers from the Monday night contest:
Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
Week 1: The New England Patriots' Robert Spillane (14) and Christian Elliss (53) tackle Las Vegas Raiders tight end Michael Mayer (87) during the second half at Gillette Stadium. The Raiders won the game, 20-13.
Week 1: New York Giants quarterback Russell Wilson (3) fumbles the ball on a tackle by Washington Commanders safety Will Harris (3) during the first quarter at Northwest Stadium. It was a rough Giants debut for Wilson (17 of 37 passing for 168 yards) as the Commanders won the game, 21-6.
Week 1: Fireworks go off before the NFL Kickoff Game between the Philadelphia Eagles and Dallas Cowboys at Lincoln Financial Field. The defending Super Bowl champion Eagles opened the season with a 24-20 victory over their longtime NFC East rivals.1 / 4Best images of the 2025 NFL season
Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
1 / 4Best images of the 2025 NFL season
Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
2 / 4Best images of the 2025 NFL season
Week 1: The New England Patriots' Robert Spillane (14) and Christian Elliss (53) tackle Las Vegas Raiders tight end Michael Mayer (87) during the second half at Gillette Stadium. The Raiders won the game, 20-13.3 / 4Best images of the 2025 NFL season
Week 1: New York Giants quarterback Russell Wilson (3) fumbles the ball on a tackle by Washington Commanders safety Will Harris (3) during the first quarter at Northwest Stadium. It was a rough Giants debut for Wilson (17 of 37 passing for 168 yards) as the Commanders won the game, 21-6.4 / 4Best images of the 2025 NFL season
Week 1: Fireworks go off before the NFL Kickoff Game between the Philadelphia Eagles and Dallas Cowboys at Lincoln Financial Field. The defending Super Bowl champion Eagles opened the season with a 24-20 victory over their longtime NFC East rivals.WINNERS
Christian McCaffrey shines against former team
San Francisco’s first five plays went to McCaffrey. The opening series was a preview of what was to come. The 49ers’ offensive gameplan centered around McCaffrey.
AdvertisementAdvertisementAdvertisementThe do-it-all running back was a busy man against his former team, gaining 89 yards on the ground with one rushing touchdown and 53 yards receiving. He had 31 total touches and 142 yards from scrimmage.
McCaffrey leads the NFL with 1,581 yards from scrimmage.
Safety Ji'Ayir Brown, 49ers defense
Defensive coordinator Robert Saleh had plenty to cheer about as San Francisco bottled up Carolina’s offense.
The 49ers defense held the Panthers to 1-7 on third downs and 230 yards of total offense.
Ji'Ayir Brown tallied two interceptions.
The 49ers defense is without its two best players in Fred Warner and Nick Bosa, who are both out for the season.
AdvertisementAdvertisementAdvertisementWarner and Bosa are irreplaceable for the 49ers, but San Francisco's playing good team defense without their two stars.
Jaycee Horn, Mike Jackson
The Panthers picked off Brock Purdy three times in the first half.
Horn made a great play on the football when he stepped in front of Jauan Jennings on a dig route and intercepted Purdy’s pass.
Horn returned the interception 14 yards to San Francisco’s 16-yard line.
Unfortunately for Carolina, Bryce Young was picked off four plays later.
Jackson intercepted a deep pass from Purdy in the end zone early in the second quarter.
The interception party wasn’t done.
AdvertisementAdvertisementAdvertisementHorn intercepted Purdy again in the middle of the field midway through the second quarter.
The Panthers offense couldn’t turn the three turnovers into many points. Carolina was only able to muster up three points off three first half turnovers.
Horn had more success catching footballs than any Panthers offensive player. No Panthers pass catcher had more than one catch in the first half.
The night ended early for Horn. Carolina ruled him out of the second half due to a concussion.
Tampa Bay Buccaneers
The result of Monday’s game restored sole possession of first place in the NFC South to the Buccaneers (6-5), despite Tampa Bay being on a three-game losing streak.
Week 6: Washington Commanders wide receiver Chris Moore (19) celebrates with teammates after scoring a touchdown during the "Monday Night Football" game against the Chicago Bears at Northwest Stadium. The Commanders wore their all-black alternate uniforms for the game.
Week 6: Atlanta Falcons running back Tyler Allgeier (25) carries the ball for a touchdown against the Buffalo Bills at Mercedes-Benz Stadium. The Falcons played the game while sporting throwback uniforms that harken back to the team's inaugural season of 1966.
Week 6: Buffalo Bills quarterback Josh Allen operates at the line of scrimmage before a play against the Atlanta Falcons during a "Monday Night Football" game at Mercedes-Benz Stadium. The Bills wore throwback uniforms reminiscent of the team's look from 1962-1973 during the game.
Week 6: Carolina Panthers quarterback Bryce Young looks for a receiver against the Dallas Cowboys at Bank of America Stadium. The Panthers wore this uniform combination for the first time in the 30-27 win.
Week 5: Buffalo Bills wide receiver Curtis Samuel makes a catch against the New England Patriots at Highmark Stadium. The Bills wore their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
Week 5: Arizona Cardinals quarterback Kyler Murray makes a throw during the third quarter against the Tennessee Titans at State Farm Stadium. The Cardinals wore their all-black uniforms, but were defeated 22-21.
Week 5: Tampa Bay Buccaneers quarterback Baker Mayfield awaits the snap against the Seattle Seahawks at Lumen Field. Both teams wore throwback uniforms in the Buccaneers' 38-35 win. The Buccaneers and Seahawks entered the NFL together as expansion teams in 1976.
Week 5: Seattle Seahawks wide receiver Tory Horton (15) is congratulated by teammate AJ Barner (88) after catching a touchdown pass against the Tampa Bay Buccaneers during the second half at Lumen Field. The Seahawks wore throwback uniforms harkening back to the team's original look from 1976-2001.
Week 5: Los Angeles Chargers running back Omarion Hampton (8) runs against the Washington Commanders during the first quarter at SoFi Stadium. The Chargers wore monochrome powder blue uniform pants and jerseys for the first time.
Week 5: New York Jets wide receiver Garrett Wilson (5) is tackled by the Dallas Cowboys' Trevon Diggs (7) and Juanyeh Thomas (2) during the first half at MetLife Stadium. The Cowboys wore their "Arctic White" uniforms for the 37-22 win.
Week 5: New York Jets quarterback Justin Fields stands in the pocket against the Dallas Cowboys during the first half at MetLife Stadium. The Jets wore their all-black uniforms in the 37-22 loss.
Week 4: Denver Broncos quarterback Bo Nix (10) hands the ball off to running back J.K. Dobbins during the "Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
Week 4: Miami Dolphins running back De'von Achane rushes the ball against the New York Jets during a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
Week 4: The Arizona Cardinals defense tackles Seattle Seahawks wide receiver Tory Horton (15) during the first quarter of a "Thursday Night Football" game at State Farm Stadium. The Cardinals became the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
Week 3: Baltimore Ravens tight end Charlie Kolar (88) makes a catch during his team's "Monday Night Football" game against the Detroit Lions at M&T Bank Stadium. The Ravens wore their all-black uniforms for the game dubbed, "Darkness Falls." Despite the fancy marketing moniker, the Ravens were defeated, 38-30.
Week 3: New Orleans Saints running back Kendre Miller (5) stiff arms Seattle Seahawks linebacker Tyrice Knight (48) during the second quarter at Lumen Field. The Saints wore their all-white uniform and helmet combo for the first time in the 44-13 loss.
Week 3: San Francisco 49ers running back Christian McCaffrey carries the ball against the Arizona Cardinals during the first half at Levi's Stadium. The 49ers wore throwback jerseys - an homage to the team's 1950s look, as well as its 1994 Super Bowl-winning season - in the 16-15 win against the Cardinals.
Week 3: New England Patriots tight end Hunter Henry (85) celebrates after scoring a touchdown against the Pittsburgh Steelers at Gillette Stadium. New England brought out its iconic "Pat Patriot" throwback in the 21-14 defeat.
Week 3: Tampa Bay Buccaneers running back Rachaad White (1) runs with the ball as New York Jets cornerback Sauce Gardner attempts to make the tackle during the second quarter at Raymond James Stadium. The Buccaneers wore their famous "Creamsicle" throwback uniforms in the 29-27 win.
Week 3: Cleveland Browns running back Quinshon Judkins celebrates after scoring a touchdown against the Green Bay Packers during the fourth quarter at Huntington Bank Field. The Browns debuted their "Alpha Dawg" alternate uniform for the 13-10 win.
Week 3: Jacksonville Jaguars cornerback Jourdan Lewis (2) celebrates after making an interception in the fourth quarter against the Houston Texans at EverBank Stadium. The Jaguars wore their "Prowler Throwbacks" - an homage to the team's late-1990s heyday - for the 17-10 win.
Week 3: Carolina Panthers tight end JaTavion Saunders runs with the ball against the Atlanta Falcons at Bank of America Stadium. The Panthers wore their special black helmets in the 30-0 win.
Week 2: Minnesota Vikings quarterback J.J. McCarthy (9) runs the ball against the Atlanta Falcons at U.S. Bank Stadium. Sporting "The Vikings Classic" throwback uniform inspired by the team's look during the 1960s and '70s, Minnesota was defeated, 22-6.
Week 2: The Green Bay Packers' Micah Parsons (1) reacts during a "Thursday Night Football" game against the Washington Commanders at Lambeau Field. The Packers wore their "Winter Warning" uniforms for the 27-18 win.
Week 1: New Orleans Saints running back Alvin Kamara scores a touchdown against the Arizona Cardinals at Caesars Superdome. The Saints wore their reimagined "Gameday Gold" uniforms for their season opener, marking the first time the team wore gold jerseys since the 2002 season. The Cardinals defeated the Saints, 20-13.1 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 6: Washington Commanders wide receiver Chris Moore (19) celebrates with teammates after scoring a touchdown during the "Monday Night Football" game against the Chicago Bears at Northwest Stadium. The Commanders wore their all-black alternate uniforms for the game.1 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 6: Washington Commanders wide receiver Chris Moore (19) celebrates with teammates after scoring a touchdown during the "Monday Night Football" game against the Chicago Bears at Northwest Stadium. The Commanders wore their all-black alternate uniforms for the game.2 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 6: Atlanta Falcons running back Tyler Allgeier (25) carries the ball for a touchdown against the Buffalo Bills at Mercedes-Benz Stadium. The Falcons played the game while sporting throwback uniforms that harken back to the team's inaugural season of 1966.3 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 6: Buffalo Bills quarterback Josh Allen operates at the line of scrimmage before a play against the Atlanta Falcons during a "Monday Night Football" game at Mercedes-Benz Stadium. The Bills wore throwback uniforms reminiscent of the team's look from 1962-1973 during the game.4 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 6: Carolina Panthers quarterback Bryce Young looks for a receiver against the Dallas Cowboys at Bank of America Stadium. The Panthers wore this uniform combination for the first time in the 30-27 win.5 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: Buffalo Bills wide receiver Curtis Samuel makes a catch against the New England Patriots at Highmark Stadium. The Bills wore their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
6 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: Arizona Cardinals quarterback Kyler Murray makes a throw during the third quarter against the Tennessee Titans at State Farm Stadium. The Cardinals wore their all-black uniforms, but were defeated 22-21.7 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: Tampa Bay Buccaneers quarterback Baker Mayfield awaits the snap against the Seattle Seahawks at Lumen Field. Both teams wore throwback uniforms in the Buccaneers' 38-35 win. The Buccaneers and Seahawks entered the NFL together as expansion teams in 1976.
8 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: Seattle Seahawks wide receiver Tory Horton (15) is congratulated by teammate AJ Barner (88) after catching a touchdown pass against the Tampa Bay Buccaneers during the second half at Lumen Field. The Seahawks wore throwback uniforms harkening back to the team's original look from 1976-2001.9 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: Los Angeles Chargers running back Omarion Hampton (8) runs against the Washington Commanders during the first quarter at SoFi Stadium. The Chargers wore monochrome powder blue uniform pants and jerseys for the first time.10 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: New York Jets wide receiver Garrett Wilson (5) is tackled by the Dallas Cowboys' Trevon Diggs (7) and Juanyeh Thomas (2) during the first half at MetLife Stadium. The Cowboys wore their "Arctic White" uniforms for the 37-22 win.11 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 5: New York Jets quarterback Justin Fields stands in the pocket against the Dallas Cowboys during the first half at MetLife Stadium. The Jets wore their all-black uniforms in the 37-22 loss.12 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 4: Denver Broncos quarterback Bo Nix (10) hands the ball off to running back J.K. Dobbins during the "Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
13 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 4: Miami Dolphins running back De'von Achane rushes the ball against the New York Jets during a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
14 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 4: The Arizona Cardinals defense tackles Seattle Seahawks wide receiver Tory Horton (15) during the first quarter of a "Thursday Night Football" game at State Farm Stadium. The Cardinals became the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
15 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: Baltimore Ravens tight end Charlie Kolar (88) makes a catch during his team's "Monday Night Football" game against the Detroit Lions at M&T Bank Stadium. The Ravens wore their all-black uniforms for the game dubbed, "Darkness Falls." Despite the fancy marketing moniker, the Ravens were defeated, 38-30.16 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: New Orleans Saints running back Kendre Miller (5) stiff arms Seattle Seahawks linebacker Tyrice Knight (48) during the second quarter at Lumen Field. The Saints wore their all-white uniform and helmet combo for the first time in the 44-13 loss.
17 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: San Francisco 49ers running back Christian McCaffrey carries the ball against the Arizona Cardinals during the first half at Levi's Stadium. The 49ers wore throwback jerseys - an homage to the team's 1950s look, as well as its 1994 Super Bowl-winning season - in the 16-15 win against the Cardinals.
18 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: New England Patriots tight end Hunter Henry (85) celebrates after scoring a touchdown against the Pittsburgh Steelers at Gillette Stadium. New England brought out its iconic "Pat Patriot" throwback in the 21-14 defeat.19 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: Tampa Bay Buccaneers running back Rachaad White (1) runs with the ball as New York Jets cornerback Sauce Gardner attempts to make the tackle during the second quarter at Raymond James Stadium. The Buccaneers wore their famous "Creamsicle" throwback uniforms in the 29-27 win.20 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: Cleveland Browns running back Quinshon Judkins celebrates after scoring a touchdown against the Green Bay Packers during the fourth quarter at Huntington Bank Field. The Browns debuted their "Alpha Dawg" alternate uniform for the 13-10 win.21 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: Jacksonville Jaguars cornerback Jourdan Lewis (2) celebrates after making an interception in the fourth quarter against the Houston Texans at EverBank Stadium. The Jaguars wore their "Prowler Throwbacks" - an homage to the team's late-1990s heyday - for the 17-10 win.22 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 3: Carolina Panthers tight end JaTavion Saunders runs with the ball against the Atlanta Falcons at Bank of America Stadium. The Panthers wore their special black helmets in the 30-0 win.23 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 2: Minnesota Vikings quarterback J.J. McCarthy (9) runs the ball against the Atlanta Falcons at U.S. Bank Stadium. Sporting "The Vikings Classic" throwback uniform inspired by the team's look during the 1960s and '70s, Minnesota was defeated, 22-6.
24 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 2: The Green Bay Packers' Micah Parsons (1) reacts during a "Thursday Night Football" game against the Washington Commanders at Lambeau Field. The Packers wore their "Winter Warning" uniforms for the 27-18 win.25 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL season
Week 1: New Orleans Saints running back Alvin Kamara scores a touchdown against the Arizona Cardinals at Caesars Superdome. The Saints wore their reimagined "Gameday Gold" uniforms for their season opener, marking the first time the team wore gold jerseys since the 2002 season. The Cardinals defeated the Saints, 20-13.LOSERS
Carolina’s complementary football (offense)
The Panthers defense picked off Brock Purdy three times in the first half.
AdvertisementAdvertisementAdvertisementHowever, Bryce Young and the Panthers offense was listless after the change of possession. Young was intercepted four plays after Carolina’s defense got its first takeaway.
The Panthers offense only managed three points off three first half takeaways by their defense.
Young and the Panthers didn’t have a drive of more than 26 yards in the first half. They had just 72 total yards at halftime.
Bad performance for Bryce Young, Panthers offense
Young recorded a Panthers franchise record 448 passing yards last week. He followed up that performance with a dud.
The Panthers quarterback tossed two interceptions in what was an offensive struggle. He passed for 169 yards, one touchdown and two interceptions.
AdvertisementAdvertisementAdvertisementYoung threw a bad interception in the red zone during the first quarter. Young’s interception came four plays after Jaycee Horn recorded an interception for Carolina.
Young had just six completions for 28 passing yards at halftime.
The Panthers went 0-2 in the red zone and only converted one first down. No pass catcher had more than 36 yards receiving.
Brock Purdy’s rough first half
Both offenses were terrible in the first half.
San Francisco’s troubles were attributed to Purdy’s three interceptions in the first half. He was off the mark on all three interceptions. The 49ers quarterback struggled with accuracy through two quarters.
AdvertisementAdvertisementAdvertisementChristian McCaffrey was the safety valve for the 49ers offense for most of the game.
Follow USA TODAY Sports' Tyler Dragon on X @TheTylerDragon.
This article originally appeared on USA TODAY: Christian McCaffrey headlines winners and losers from 49ers' MNF win
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